Lifespan by David A. Sinclair – Book Review


You can’t turn back time – but you can turn back your body clock! You can become physiologically younger while growing chronologically older. This book by Dr David Sinclair points you in the right direction.

I would guess that about 80% of what we read and watch about anti aging focuses on the way we look – cosmetics, skin treatments, beauty gadgets, facelifts, fillers and so on. Maybe 15% of what we see concentrates on how we feel – exercise, diets, meditation, brain training, psychotherapy, etc. And I’m estimating that only about 5% of material attacks the questions we all want answered – how do I physcially become younger? How do I turn my body clock back? How can I get back what I’ve lost? How can I prevent getting any older than I am today? I want to live a long, long, life – how can I do that while staying healthy enough to enjoy it? And only a tiny fraction of what we see is written by someone who has the expertise to tell you the answeres with any authority to do so.

Dr David Sinclair

Dr David Sinclair is one who does. He’s  Harvard Professor in the Department of Genetics, and is co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. Here’s a little of what Harvard says about him – “Dr. Sinclair is co-founder of several biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. His work is featured in five books, two documentary movies, 60 Minutes, Morgan Freeman’s “Through the Wormhole” and other media. He is an inventor on 35 patents and has received more than 25 awards and honors including the CSL Prize, The Australian Commonwealth Prize, Thompson Prize, Helen Hay Whitney Postdoctoral Award, Charles Hood Fellowship, Leukemia Society Fellowship, Ludwig Scholarship, Harvard-Armenise Fellowship, American Association for Aging Research Fellowship, Nathan Shock Award from the National Institutes of Health, Ellison Medical Foundation Junior and Senior Scholar Awards, Merck Prize, Genzyme Outstanding Achievement in Biomedical Science Award, Bio-Innovator Award, David Murdock-Dole Lectureship, Fisher Honorary Lectureship, Les Lazarus Lectureship, Australian Medical Research Medal, The Frontiers in Aging and Regeneration Award, Top 100 Australian Innovators, and TIME magazine’s list of the “100 most influential people in the world”.”

Qualified? I’d say so!

His book, as you can imagine, is quite science-based, but is still an easy read. As to content, you won’t find anything in here about cosmetics, fillers, and facelifts. You will find some amazing information about diet and exercise, but only as it relates to longevity and rejuvenation – basically, living longer and growing younger! No bodybuilding techniques or muscle pumping in this book.

Where this books really excels in the discussing Dr Sinclair’s research into how and why we age, and what do do in practise to reverse the aging we have already undergone, and prevent more. It’s all to do with genetics, (as you would imagine from a Professor of Genetics!) and how specific genes you inherited are designed to make you age. He discusses the 3 levels of antiaging – firstly, avoiding obvious damage like smoking and a poor diet. Secondly, turning off temporarily those genes that age you through slightly more aggressive approaches like intermittent fasting and cold water treatments, along with some medical and supplements that are already available today.

And then finally, the third, he calls it “deep” level of antiaging, to permanently turn off those aging genes, using some extra supplements you can get and even some he and his team have designed himself. One is very well known and you may have heard of – resveratrol, which is derived from red wine. Due to a corporate attack from a rival, his work on this, and resveratrol itself, was temporarily discredited, but he spent three years proving he was right and resveratrol works. He takes it himself, what more can I say? I like a man who puts his money where his mouth is! (I’ll be putting a link on the products page).

Dr Sincair is now very well known in the world of rejuvenation and longevity – you can see him speaking at TedTalks, Youtube, and TV. He’s easy to listen to,  and a great advert for his own work, being 50 and looking like a very cute 35 year old!

I can thoroughly recommend both this book, and following the advice within. In other postings, I’ll be reviewing the supplements and the treatments. But for now, let me just say that it’s a good idea to read the book more than once to get the most benefit. Did you know that the first time we read something or hear it, we take in a maximum of 60% of the information and an average of 40%? In order to get the most benefit, we need to read, or watch, several times to make sure we don’t miss a vital bit! I’m still re-reading this one and re-viewing some of his interviews , and I still find I’m discovering facts I missed the first time!

Definitely 5 stars. I personally recommend it!



Book title – Lifespan, Why we age and why we don’t have to.

Author – Dr David A. Sinclair

ISBN – 978-0-00-835374-2

Publisher – Thorsons

Link to Amazon US site –

Link to Amazon UK site –


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